Key result
Carotid artery distensibility and stroke volume to pulse pressure ratio were independently associated with the Framingham risk score in 70-year-olds (P<0.0001 for both).
Why the study?
How do three different methods of determining arterial compliance compare in feasibility and relation to cardiac risk in an elderly population?
Observational (n=1,016)
How do three different methods of determining arterial compliance compare in feasibility and relation to cardiac risk in an elderly population?
p-value: p=<0.0001
Carotid artery distensibility and stroke volume to pulse pressure ratio are independently related to coronary risk in the elderly, suggesting their complementary use in evaluating arterial compliance.
Should not yet change elderly risk assessment; leaves open incremental value beyond Framingham score.
BACKGROUND: Several different techniques to evaluate arterial compliance have been described but have not been simultaneously tested in a large-scale, population-based setting. This study aimed to evaluate the feasibility and relation to cardiac risk of three of these techniques in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study. METHODS AND RESULTS: In the population-based PIVUS study (1016 participants aged 70), assessment of arterial distensibility by ultrasound in the carotid artery, by pulse wave analysis (augmentation index) and the stroke volume to pulse pressure ratio by echocardiography were successfully employed in 86, 92, 91 and 77% of the sample, respectively. All three indices of arterial compliance were inter-related (r = 0.19-0.34, P < 0.0001 for all). Although all three indices were significantly related to the Framingham risk score (r = 0.12-0.32, P = 0.0005-0.0001), only carotid artery distensibility and the stroke volume to pulse pressure ratio were independently associated with the Framingham score in multiple regression analysis (P < 0.0001 for both). CONCLUSIONS: All three indices to evaluate arterial compliance were feasible to obtain in a general elderly population and were inter-related. Although all of the techniques were correlated to Framingham risk score, only carotid artery distensibility and the stroke volume to pulse pressure ratio were independently related to coronary risk, suggesting complementary use of these two indices of arterial compliance in the future.
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Lind et al. (2006) conducted an observational in General elderly population (n=1,016). Arterial compliance assessment (carotid distensibility, augmentation index, stroke volume to pulse pressure ratio) was evaluated on Independent association with Framingham risk score (p=<0.0001). Carotid artery distensibility and stroke volume to pulse pressure ratio were independently associated with the Framingham risk score in 70-year-olds (P<0.0001 for both).
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