Key result
CT imaging revealed peripheral ground-glass opacities suggesting peribronchial injury, aiding in the early recognition of severe swine-origin influenza A despite false-negative rapid antigen tests.
Case Report (n=1)
CT imaging may play a role in the early recognition of severe swine-origin influenza A (H1N1) infection, especially when rapid antigen tests are falsely negative.
May support early CT consideration in suspected severe H1N1 with negative antigen tests; hypothesis-generating and requires prospective validation.
OBJECTIVE: Although most cases of swine-origin influenza A (H1N1) virus (S-OIV) have been self-limited, fatal cases raise questions about virulence and radiology's role in early detection. We describe the radiographic and CT findings in a fatal S-OIV infection. CONCLUSION: Radiography showed peripheral lung opacities. CT revealed peripheral ground-glass opacities suggesting peribronchial injury. These imaging findings raised suspicion of S-OIV despite negative H1N1 influenza rapid antigen test results from two nasopharyngeal swabs; subsequently, those results were proven to be false-negatives by reverse transcriptase polymerase chain reaction. This case suggests a role for CT in the early recognition of severe S-OIV.
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Mollura et al. (2009) conducted a case report in Swine-origin influenza A (H1N1) (n=1). Radiography and CT imaging was evaluated on Radiographic and CT findings. CT imaging revealed peripheral ground-glass opacities suggesting peribronchial injury, aiding in the early recognition of severe swine-origin influenza A despite false-negative rapid antigen tests.
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