What question did this study set out to answer?

To evaluate differences in motor decline trajectories between older adults who develop mild cognitive impairment and those who remain cognitively intact, and determine when motor slowing accelerates.

August 1, 2010Archives of NeurologyOpen Access

The Trajectory of Gait Speed Preceding Mild Cognitive Impairment

View Full Paper

Ask AI

Bookmark

To evaluate differences in motor decline trajectories between older adults who develop mild cognitive impairment and those who remain cognitively intact, and determine when motor slowing accelerates.
Longitudinal cohort study evaluating 204 healthy seniors (57.8% women) from the Oregon Brain Aging Study for up to 20 years using annual neurologic, neuropsychological, and motor testing.
Motor decline patterns and acceleration points for gait speed and finger-tapping speed were estimated using mixed-effects models with interaction terms and change-point analyses.
Decline rates over time for gait speed (P < .001) and finger-tapping speed in both dominant (P = .003) and nondominant hands (P < .001) differed significantly between participants who developed mild cognitive impairment and nonconverters.
In participants developing mild cognitive impairment, gait speed decline accelerated by 0.023 m/s/year (P < .001) beginning 12.1 years prior to diagnosis (occurring earlier in men than women), whereas finger-tapping deceleration accelerated only after diagnosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

A longitudinal cohort study finds that gait speed decline accelerates 12 years before mild cognitive impairment onset in older adults, suggesting motor changes serve as early preclinical markers.

Cite This Study

Buracchio et al. (2010) studied this question.

synapsesocial.com/papers/6a11e90e9ffe35dda08e1390 https://doi.org/10.1001/archneurol.2010.159

View Full Paper

Ask AI

Bookmark

Implication

A longitudinal cohort study finds that gait speed decline accelerates 12 years before mild cognitive impairment onset in older adults, suggesting motor changes serve as early preclinical markers.

The Trajectory of Gait Speed Preceding Mild Cognitive Impairment

Key Points

Discussion

Implication

Cite This Study

The Trajectory of Gait Speed Preceding Mild Cognitive Impairment

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider