Key result
Cardiac autonomic tone parameters (HRV, BPV, and BRS) were depressed in patients with SCA1 and SCA2 compared to healthy controls, with no significant difference between the two SCA subtypes.
Why the study?
To assess time and frequency domain measures of cardiac autonomic tone in genetically defined SCA types 1 and 2, and evaluate associations with genetic and clinical characteristics.
Are cardiac autonomic tone parameters (HRV, BPV, BRS) depressed in patients with spinocerebellar ataxia types 1 and 2 compared to healthy controls?
Cross-Sectional (n=111)
Are cardiac autonomic tone parameters (HRV, BPV, BRS) depressed in patients with spinocerebellar ataxia types 1 and 2 compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Cardiac autonomic tone is depressed in patients with spinocerebellar ataxia types 1 and 2 compared to healthy controls, and correlates with disease characteristics.
OBJECTIVES: To assess the time and frequency domain measures of cardiac autonomic activity/tone in patients of genetically defined spinocerebellar ataxia (SCA) types 1 and 2, as well as to decipher the probable associations among the cardiovascular autonomic parameters and genetic and clinical characteristics. MATERIALS AND METHODS: Simultaneous 5-min recording of RR interval (RRI) and blood pressure (BP) for the calculation of heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) were performed in genotypically confirmed SCA1 (n = 31) and SCA2 (n = 40) patients and healthy controls (n = 40). Additionally, the International Cooperative Ataxia Rating Scale (ICARS) was used for scoring of clinical severity in SCA patients. RESULTS: Time and frequency domain parameters of HRV, BPV and BRS were depressed in SCA1 and SCA2 subtypes as compared to controls, although there was no statistically significant difference in autonomic tone between the two SCA subtypes. On correlation analysis, autonomic tone parameters were found to be associated with the clinical and genetic features of the SCA subtypes. Also, ICARS was associated with the genotype (CAG repeat length) in SCA2 patents. CONCLUSIONS: Cardiac autonomic tone is depressed in both SCA1 and 2 as compared to healthy controls while the two SCA subtypes do not differ in terms of autonomic tone. Also, a typical association exists between disease characteristics and autonomic indices.
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Tamuli et al. (2019) conducted a cross-sectional in Spinocerebellar ataxia (SCA) types 1 and 2 (n=111). Spinocerebellar ataxia type 1 and 2 vs. Healthy controls was evaluated on Time and frequency domain measures of cardiac autonomic activity/tone (HRV, BPV, BRS). Cardiac autonomic tone parameters (HRV, BPV, and BRS) were depressed in patients with SCA1 and SCA2 compared to healthy controls, with no significant difference between the two SCA subtypes.
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