Key result
Systemic sclerosis was associated with a significantly higher heart rate and lower circadian and spectral indices of heart rate variability compared with healthy controls (P<0.01).
Why the study?
Do patients with systemic sclerosis exhibit autonomic dysfunction as measured by 24-hour heart rate variability compared to healthy controls?
Case-Control (n=60)
Do patients with systemic sclerosis exhibit autonomic dysfunction as measured by 24-hour heart rate variability compared to healthy controls?
p-value: p=<0.01
Patients with systemic sclerosis exhibit significant autonomic cardiac neuropathy characterized by reduced heart rate variability, which is predictive of mortality.
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Indicates possible autonomic dysfunction in systemic sclerosis; leaves open prognostic value and need for prospective validation.
Ferri et al. (1997) conducted a case-control in Systemic sclerosis (n=60). Systemic sclerosis vs. Healthy subjects was evaluated on Heart rate and heart rate variability (circadian and spectral indices) (p=<0.01). Systemic sclerosis was associated with a significantly higher heart rate and lower circadian and spectral indices of heart rate variability compared with healthy controls (P<0.01).
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