Key result
Systemic sclerosis was associated with significantly reduced supine heart rate variability compared to primary Raynaud's phenomenon (1103 vs 3302 ms2, P<0.004) and controls (3148 ms2, P<0.002).
Why the study?
Does systemic sclerosis or primary Raynaud's phenomenon alter autonomic function and heart rate variability compared to healthy controls?
Population
36 subjects, including 10 patients with systemic sclerosis, 12 patients with primary Raynaud's phenomenon…
Design
Cross-sectional
Authors
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Does not support routine HRV monitoring in systemic sclerosis; hypothesis-generating for autonomic dysfunction and outcomes.
Observational (n=36)
Does systemic sclerosis or primary Raynaud's phenomenon alter autonomic function and heart rate variability compared to healthy controls?
Absolute Event Rate: 1103% vs 3148%
p-value: p=<0.002
Patients with systemic sclerosis exhibit reduced heart rate variability, increased sympathetic output, and impaired baroreceptor modulation, which correlates with indices of respiratory insufficiency.
Pancera et al. (1999) conducted an observational in Systemic sclerosis and primary Raynaud's phenomenon (n=36). Systemic sclerosis vs. Primary Raynaud's phenomenon and controls was evaluated on Heart rate variability (total power) in supine position (p=<0.002). Systemic sclerosis was associated with significantly reduced supine heart rate variability compared to primary Raynaud's phenomenon (1103 vs 3302 ms2, P<0.004) and controls (3148 ms2, P<0.002).
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