Key result
Hypertension in ischemic stroke patients (n=768 vs 705 controls) was directly associated with lacunar syndrome, female gender, and previous infarction, and inversely associated with age ≥85 years.
Why the study?
What are the differences in risk factors, clinical features, neuroimaging data, and outcomes between hypertensive and non-hypertensive ischemic stroke patients?
Observational (n=1,473)
What are the differences in risk factors, clinical features, neuroimaging data, and outcomes between hypertensive and non-hypertensive ischemic stroke patients?
Hypertension in ischemic stroke is primarily associated with small- and large-artery disease phenotypes, specifically lacunar and atherothrombotic infarctions.
Supports hypertension-linked phenotyping in stroke classification; leaves open causal mechanisms and need for prospective validation.
We compared risk factors, clinical features, neuroimaging data, and outcome between hypertensive and non-hypertensive ischemic stroke patients. Differential features of ischemic stroke patients with hypertension (n = 768) and without hypertension (n = 705) were assessed by bivariate analysis. Independent predictors of hypertensive ischemic stroke were determined by multivariate analysis. Atherothrombotic infarction and lacunar infarct were significantly more common in the hypertensive group, in which older age and a higher occurrence of previous cerebral infarction, hyperlipidemia, acute stroke onset, lacunar syndrome, and pons topography was also observed. Age of 85 years or older, valvular heart disease, and decreased consciousness were more common in non-hypertensive patients. After multivariate analysis, lacunar syndrome, female gender, and previous infarction were directly associated with hypertensive ischemic stroke. Age of 85 years or older and valvular heart disease were inversely associated with hypertensive ischemic stroke. Hypertension was the main cardiovascular risk factor only for lacunes and atherothrombotic infarction, that is, ischemic stroke associated with small- and large-artery disease.
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Arboix et al. (2004) conducted an observational in Ischemic stroke (n=1,473). Hypertension vs. Without hypertension was evaluated on Predictors of hypertensive ischemic stroke. Hypertension in ischemic stroke patients (n=768 vs 705 controls) was directly associated with lacunar syndrome, female gender, and previous infarction, and inversely associated with age ≥85 years.
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