Key result
Poor baseline quality of life in PCI patients is linked to ~185% higher 1-year mortality.
Why the study?
Poor quality of life is an independent risk factor for mortality and MACE in CVD, but its baseline association with outcomes after PCI across sex and age groups required assessment.
Is poor baseline health-related quality of life associated with increased mortality and MACE at 1 year in patients undergoing PCI?
Cohort (n=15,198)
Is poor baseline health-related quality of life associated with increased mortality and MACE at 1 year in patients undergoing PCI?
Effect estimate: HR 2.85 (95% CI 1.76-4.62)
p-value: p=<0.001
Poor baseline health-related quality of life is a strong independent predictor of 1-year mortality and MACE in patients undergoing PCI.
Poor baseline QoL signals higher post-PCI mortality and MACE risk; leaves open whether QoL-targeted interventions improve outcomes.
Background and aim: poor quality of life (QoL) has been identified as an independent risk factor for mortality and major cardiac events (MACE) in patients with cardiovascular disease (CVD). The aim of this study was to assess health-related quality of life (HRQoL) at baseline and its association with outcome in patients with coronary artery disease presenting for percutaneous coronary intervention (PCI). The outcome was measured by mortality and MACE at 1-year, and whether there was any difference for sex and different age groups. Methods and results: all patients prospectively enrolled into the GenesisCare Outcome Registry (GCOR) over a 11-year period were included in the study. The EQ-5D-5L and VAS patient survey were used for assessment of baseline HRQoL. Of the 15,198 patients, only 6591 (43.4%) completed the self-assessment. Women had significantly more impairment of all five dimensions of the EQ-5D-5L survey, and their self-reported QoL was significantly lower than men (68.3 in women vs. 71.9 in men, p < 0.001). Poor QoL was strongly associated with increased mortality (HR 2.85; 95% CI 1.76 to 4.62, p < 0.001) and MACE (HR 1.40; 95% CI 1.10 to 1.79, p = 0.01). A similar trend was noted for women and men, but did not reach significance in women due to the smaller number of female patients. Conclusion: poor HRQoL is associated with subsequent mortality and MACE in patients undergoing PCI. By not assessing quality of life as a standard of care, an opportunity is lost to identify high-risk patients who may benefit from targeted interventions to improve health outcomes.
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Conradie et al. (2022) conducted a cohort in Coronary artery disease (n=15,198). Poor health-related quality of life (HRQoL) vs. Better HRQoL was evaluated on Mortality at 1-year (HR 2.85, 95% CI 1.76-4.62, p=<0.001). Poor baseline health-related quality of life in patients undergoing PCI was strongly associated with increased 1-year mortality (HR 2.85; 95% CI 1.76-4.62; p<0.001) and MACE (HR 1.40; p=0.01).
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