Key result
Warfarin showed similar rates of thromboembolic events compared to placebo but increased the risk of bleeding in patients with systolic heart failure without other indications.
Why the study?
Does oral anticoagulation with warfarin prevent thromboembolic events in patients with systolic heart failure?
Does oral anticoagulation with warfarin prevent thromboembolic events in patients with systolic heart failure?
Current available data do not support the use of warfarin in patients with systolic heart failure in the absence of a specific indication, as it does not reduce thromboembolic events and increases bleeding risk.
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Does not support routine warfarin in systolic HF without indications; leaves open need for RCTs on anticoagulation strategies.
Snowden et al. (2010) conducted a review in Left ventricular systolic dysfunction / Systolic heart failure. Warfarin vs. Placebo was evaluated on Thromboembolic events. Warfarin showed similar rates of thromboembolic events compared to placebo but increased the risk of bleeding in patients with systolic heart failure without other indications.
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