November 1, 1990Journal of Biological ChemistryOpen Access

Inactivation of splicing factors in HeLa cells subjected to heat shock

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Population

HeLa cells

Comparison

Heat shock at 43 or 46 degrees C for 2 h or in… vs Normal HeLa cells / normal nuclear extract

Design

Preclinical

Authors

RSR R Shukla ZDZ DominskiUniversity of North Carolina at Chapel Hill TZT Zwierzynski

Discussion

Member takes

Implication

Heat shock disrupts splicing in vitro; leaves open relevance to stress responses in cardiovascular cells.

Structured PICO

Population

HeLa cells

Intervention

Heat shock at 43 or 46 degrees C for 2 h (in vivo) or in vitro heat treatment

Comparator

Normal HeLa cells / normal nuclear extract

Outcome

Splicing activity and snRNP complex integritysurrogate

Heat shock at 43 or 46 degrees C inactivates specific protein splicing factors and disrupts snRNP complexes in HeLa cells, preventing functional spliceosome formation.

Cite This Study

Shukla et al. (1990) studied this question.

synapsesocial.com/papers/6a11fe5af460874a04d205b0 https://doi.org/10.1016/s0021-9258(17)30514-8

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Inactivation of splicing factors in HeLa cells subjected to heat shock

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inactivation of splicing factors in HeLa cells subjected to heat shock

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider