Key result
Therapies targeting cellular communication within the cardiac microenvironment show promise for treating pathological cardiac conditions.
Why the study?
Heart regenerative medicine is evolving, and understanding cellular communication between all cardiac cell types during homeostasis and injury holds promise for new therapeutic approaches.
This review highlights the evolving understanding of the cardiac microenvironment and the potential of matrix-, vascular-, and immune-targeted therapies for heart regeneration.
May inform future cardiac regeneration strategies; leaves open clinical translation of microenvironment-targeted therapies.
Heart regenerative medicine has been gradually evolving from a view of the heart as a nonregenerative organ with terminally differentiated cardiac muscle cells. Understanding the biology of the heart during homeostasis and in response to injuries has led to the realization that cellular communication between all cardiac cell types holds great promise for treatments. Indeed, recent studies highlight new disease-reversion concepts in addition to cardiomyocyte renewal, such as matrix- and vascular-targeted therapies, and immunotherapy with a focus on inflammation and fibrosis. In this review, we will discuss the cross-talk within the cardiac microenvironment and how specific therapies aim to target the hostile cardiac milieu under pathological conditions.
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Tzahor et al. (2022) conducted a review in Cardiac injury and pathological conditions. Microenvironment-targeted therapies (matrix, vascular, immunotherapy) was evaluated. Cellular communication within the cardiac microenvironment and targeted therapies focusing on matrix, vasculature, and inflammation hold great promise for treating pathological cardiac conditions.
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