Key result
Obese adolescents (especially with type 2 diabetes) had significantly higher myocardial extracellular volume fraction than healthy volunteers (median 0.376 vs 0.328 vs 0.264; P=0.0001).
Cross-Sectional (n=33)
p-value: p=0.0001
Obese adolescents, particularly those with type 2 diabetes, exhibit subclinical myocardial tissue remodeling detectable by CMR extracellular volume fraction before overt changes in cardiac function or hypertrophy occur.
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May signal early remodeling in obese youth; hypothesis-generating for ECV as pediatric biomarker, with no practice change warranted.
Shah et al. (2013) conducted a cross-sectional in Adolescent obesity (n=33). Obesity (with or without type 2 diabetes) vs. Healthy volunteers was evaluated on Interstitial matrix expansion by CMR extracellular volume fraction (ECV) (p=0.0001). Obese adolescents (especially with type 2 diabetes) had significantly higher myocardial extracellular volume fraction than healthy volunteers (median 0.376 vs 0.328 vs 0.264; P=0.0001).
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