Key result
Doxycycline lowers hemodynamic force RMS by ~32% versus healthy controls in HFpEF mice.
Why the study?
The study was conducted to longitudinally assess left ventricle global longitudinal strain and hemodynamic forces during the early stages of cardiac dysfunction in a mouse model of HFpEF.
Does doxycycline-accelerated HFpEF in db/db mice alter global longitudinal strain and hemodynamic forces compared to healthy controls?
Population
Control mice (n = 6) and db/db mice (n = 7) aged 11-15 weeks
Comparison
Doxycycline-treated db/db mice vs control mice
Design
Longitudinal preclinical imaging study
Follow-up
Between the age of 11-15 weeks
Authors
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Hemodynamic forces may detect early HFpEF dysfunction in mice before EF or GLS changes; leaves open human validation as a CMR biomarker.
Does doxycycline-accelerated HFpEF in db/db mice alter global longitudinal strain and hemodynamic forces compared to healthy controls?
Absolute Event Rate: 90% vs 133%
p-value: p=0.01
Hemodynamic forces derived from standard CINE-CMR images can detect early cardiac dysfunction in a mouse model of HFpEF before changes in ejection fraction or global longitudinal strain occur.
Daal et al. (2022) studied Heart failure with preserved ejection fraction (HFpEF) (n=13). Doxycycline vs. Healthy control mice was evaluated on Hemodynamic force root mean square (HDF RMS) (p=0.01). In a mouse model of HFpEF, db/db mice treated with doxycycline exhibited significantly lower hemodynamic force root mean square values compared to healthy controls (90% vs 133%, p=0.01).
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