Key result
Loss of LV temporal synchrony impairs hemodynamic forces more significantly than spatial dyssynchrony.
Why the study?
Modification of hemodynamic forces due to abnormal wall motions in the left ventricle and their relative impact on force balance were not fully understood.
Population
Model left ventricle
Comparison
Loss of temporal synchrony vs loss of spatial uniformity in wall motion
Design
Preclinical modeling study
Authors
Loading...
Highlights temporal dyssynchrony as greater hemodynamic disruptor in animal LV models; leaves open human relevance and CRT targeting.
In a model left ventricle, loss of temporal synchrony impacts hemodynamic forces more than loss of spatial uniformity.
Domenichini et al. (2016) studied this question. Loss of temporal synchrony in left ventricular wall motion alters hemodynamic forces more significantly than loss of spatial uniformity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: