Key result
Dilated cardiomyopathy was associated with significantly larger SAx-max/LAx-max ratios during early (0.53 vs 0.23, P<0.0001) and late (0.44 vs 0.26, P<0.03) diastolic filling than healthy subjects.
Why the study?
Does 4D flow MRI detect differences in LV hemodynamic filling forces between healthy subjects and patients with dilated cardiomyopathy?
Case-Control (n=20)
Does 4D flow MRI detect differences in LV hemodynamic filling forces between healthy subjects and patients with dilated cardiomyopathy?
Absolute Event Rate: 0.53% vs 0.23%
p-value: p=<0.0001
4D flow MRI reveals that patients with dilated cardiomyopathy have altered, more heterogeneous LV hemodynamic filling forces compared to healthy subjects.
Authors
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4D flow MRI detects altered LV filling forces in DCM; hypothesis-generating for diagnostic use pending prospective validation.
Eriksson et al. (2016) conducted a case-control in Dilated cardiomyopathy (n=20). Dilated cardiomyopathy vs. Healthy subjects was evaluated on SAx-max/LAx-max ratio for early (E-wave) diastolic filling (p=<0.0001). Dilated cardiomyopathy was associated with significantly larger SAx-max/LAx-max ratios during early (0.53 vs 0.23, P<0.0001) and late (0.44 vs 0.26, P<0.03) diastolic filling than healthy subjects.
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