December 1, 2014Physics of Fluids
Effect of the mitral valve on diastolic flow patterns
Key result
Computational simulations demonstrated that a normal physiological mitral valve promotes a circulatory flow pattern and increases apical flow strength compared to a diode-type valve model.
Why the study?
Does a physiological mitral valve model alter diastolic flow patterns compared to a diode type valve model in a computational left ventricle model?
Population
Computational model of the left ventricle based on a high-resolution contrast computed-tomography scan, and…
Comparison
Physiological mitral valve model vs Diode type valve model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Computational mitral valve flow models are hypothesis-generating; prospective validation required before clinical relevance.
Structured PICO
Does a physiological mitral valve model alter diastolic flow patterns compared to a diode type valve model in a computational left ventricle model?
P
Population
Computational model of the left ventricle based on a high-resolution contrast computed-tomography scan, and a physiological inspired model of the mitral valve leaflets synthesized from morphological and echocardiographic data
I
Intervention
Physiological mitral valve model
C
Comparator
Diode type valve model
O
Outcome
Intraventricular flow patterns (diastolic flow)surrogate
Computational simulations demonstrate that physiological mitral valve leaflets are essential for promoting normal circulatory flow patterns and enhancing apical washout in the left ventricle.
Cite This Study
Seo et al. (2014) studied Left ventricular diastolic flow. Physiological mitral valve model vs. Diode type valve model was evaluated on Intraventricular flow patterns. Computational simulations demonstrated that a normal physiological mitral valve promotes a circulatory flow pattern and increases apical flow strength compared to a diode-type valve model.