Key result
Major depressive disorder was independently associated with higher C-reactive protein levels (median 2.7 vs 1.3 mg/L; unstandardized β = 0.387, p = 0.04) in subjects at high risk of sleep apnea.
Why the study?
Are major depressive disorder and anxiety disorders associated with elevated cardiac biomarkers (CRP, cTnT, HRV) in subjects at high risk of obstructive sleep apnea?
Cross-Sectional (n=290)
Are major depressive disorder and anxiety disorders associated with elevated cardiac biomarkers (CRP, cTnT, HRV) in subjects at high risk of obstructive sleep apnea?
Effect estimate: unstandardized β = 0.387
Absolute Event Rate: 2.7% vs 1.3%
p-value: p=0.04
In patients at high risk for obstructive sleep apnea, major depressive disorder is associated with increased systemic inflammation (CRP) but not with myocardial damage (cTnT) or altered heart rate variability.
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MDD may link to inflammation rather than cardiac injury in high OSA-risk patients; hypothesis-generating for causality and prospective trials.
Einvik et al. (2011) conducted a cross-sectional in High risk of obstructive sleep apnea (n=290). Major depressive disorder (MDD) and/or anxiety disorders vs. Nondepressive and nonanxious subjects was evaluated on Circulating C-reactive protein (CRP) levels (unstandardized β = 0.387, p=0.04). Major depressive disorder was independently associated with higher C-reactive protein levels (median 2.7 vs 1.3 mg/L; unstandardized β = 0.387, p = 0.04) in subjects at high risk of sleep apnea.
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