Key result
CRP is linked to generalized anxiety disorder in stable CHD outpatients.
Why the study?
The study aimed to comprehensively evaluate MDD, anxiety disorder, and comorbid MDD and anxiety disorder alongside cardiac biomarkers including CRP, TnT, and NT-proBNP in stable CHD patients.
Is there an association between cardiac biomarkers (CRP, TnT, NT-proBNP) and psychiatric disorders in stable coronary heart disease patients?
Cross-Sectional (n=120)
Is there an association between cardiac biomarkers (CRP, TnT, NT-proBNP) and psychiatric disorders in stable coronary heart disease patients?
p-value: p=0.04
In stable coronary heart disease outpatients, elevated C-reactive protein levels are associated with generalized anxiety disorder.
May support psychiatric screening in stable CHD; cross-sectional data leave open causal links to CRP, TnT, or NT-proBNP.
AIMS: Comprehensive evaluation of major depressive disorder (MDD), anxiety disorder, and MDD in conjunction with anxiety disorder in stable coronary heart disease (CHD) patients, including cardiac biomarkers such as C-reactive protein (CRP), troponin T (TnT), and amino-terminal pro-B-type brain natriuretic peptide (NT-proBNP). METHODS AND RESULTS: Cross-sectional study of a consecutive series of 120 stable CHD outpatients (n = 30 with MDD, n = 30 with anxiety disorder, n = 30 with MDD and anxiety disorder, n = 30 with no psychiatric disorder). Psychiatric diagnoses were established by using the structured clinical interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV). Binomial logistic regression analyses using cut-off scores of biomarkers as dependent variables showed associations between CRP and generalized anxiety disorder (GAD) (P = 0.04), and education (P = 0.004), whereas MDD, and MDD and anxiety disorder did not reach the significance level. TnT showed relationships with hyperlipidaemia (P = 0.009), history of obesity or overweight (P = 0.04), and education (P = 0.04). NT-proBNP was associated with type II diabetes (P = 0.005). CONCLUSION: After adjusting for relevant demographic, medical, and psychiatric co-variables, CRP was associated with GAD.
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Bankier et al. (2008) conducted a cross-sectional in stable coronary heart disease (n=120). C-reactive protein (CRP) was evaluated on generalized anxiety disorder (GAD) (p=0.04). In stable coronary heart disease outpatients, C-reactive protein was significantly associated with generalized anxiety disorder (P=0.04).
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