Key result
Roux-en-Y gastric bypass in women resulted in a 45 ± 1 kg weight decrease and a 10 ± 2 ng/mL increase in serum 25(OH)D at 1 year, with weight and fat mass changes associated with 25(OH)D change.
Why the study?
Does Roux-en-Y gastric bypass affect serum 25(OH)D levels in women?
Cohort (n=20)
Does Roux-en-Y gastric bypass affect serum 25(OH)D levels in women?
Weight loss following Roux-en-Y gastric bypass is associated with increased serum 25(OH)D levels, though low levels may persist in some patients at 1 year.
Weight loss after RYGB was associated with higher 25(OH)D in women; leaves open optimal monitoring and supplementation post-bariatric surgery.
OBJECTIVE: To describe serum 25(OH)D changes after Roux-en-Y gastric bypass (RYGB) and to determine if fat mass (FM) loss and vitamin D intake are associated with changes in serum levels. DESIGN AND METHODS: The relationship between serum 25(OH)D and 1) FM, 2) weight, 3) % excess weight loss (EWL), and 4) BMI was investigated after controlling for potential confounders using a mixed effects linear model in 20 women before and up to 1-year post-RYGB. Subcutaneous (SAT) and visceral adipose tissue (VAT) vitamin D concentrations at time of RYGB were also evaluated. RESULTS: Weight and FM decreased 1-year after surgery by 45 ± 1 kg and 37 ± 1 kg, respectively while 25(OH)D increased by 10 ± 2 ng mL(-1) . Weight, FM, BMI, and %EWL changes were associated with 25(OH)D change. VAT had an average 21% more vitamin D per gram than SAT and concentrations were highly correlated. CONCLUSIONS: Although weight loss may lead to increased serum 25(OH)D after RYGB, low levels remain a concern in some patients 1-year postsurgery. Additional research is needed to clarify the relationship between adipose storage of vitamin D and serum 25(OH)D in obesity, and how that relationship might change after surgery. This could lead to improved clinical management of vitamin D in this ever-growing clinical population.
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Beckman et al. (2013) conducted a cohort in Obesity (n=20). Roux-en-Y gastric bypass (RYGB) vs. Pre-surgery baseline was evaluated on Change in serum 25(OH)D and its relationship with fat mass, weight, % excess weight loss, and BMI. Roux-en-Y gastric bypass in women resulted in a 45 ± 1 kg weight decrease and a 10 ± 2 ng/mL increase in serum 25(OH)D at 1 year, with weight and fat mass changes associated with 25(OH)D change.
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