Why the study?
Does sleep blood pressure and dipping pattern measured by 24-hour ambulatory monitoring predict all-cause mortality in patients referred for ambulatory monitoring?
Population
3957 patients aged 55+/-16 (58% treated) referred for ambulatory monitoring between 1991 and 2005.
Comparison
24-hour ambulatory blood pressure monitoring… vs Awake blood pressure or normal dipping patterns
Design
Cohort
Follow-up
27 750 person-years
Key result
Sleep hypertension (≥120/70 mm Hg) was significantly associated with increased all-cause mortality (HR 1.67; 95% CI 1.25-2.23), and reduced systolic dipping further increased mortality risk.
Authors
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May aid mortality risk stratification beyond clinic BP; leaves open whether targeting sleep hypertension improves outcomes.
Cohort (n=3,957)
Does sleep blood pressure and dipping pattern measured by 24-hour ambulatory monitoring predict all-cause mortality in patients referred for ambulatory monitoring?
Effect estimate: HR 1.67 (95% CI 1.25 to 2.23)
Ambulatory blood pressure monitoring, particularly sleep blood pressure and dipping patterns, provides significant predictive information for all-cause mortality beyond clinic blood pressure.
Ben‐Dov et al. (2007) conducted a cohort in Hypertension / Referred for ambulatory monitoring (n=3,957). Sleep hypertension (≥120/70 mm Hg) vs. Non-sleep hypertension / Normal dipping was evaluated on All-cause mortality (HR 1.67, 95% CI 1.25 to 2.23). Sleep hypertension (≥120/70 mm Hg) was significantly associated with increased all-cause mortality (HR 1.67; 95% CI 1.25-2.23), and reduced systolic dipping further increased mortality risk.