What question did this study set out to answer?

To provide an updated synthesis of the history, etiology, transmission epidemiology, clinical presentation, and public health dimensions of plague caused by Yersinia pestis.

January 1, 1997Clinical Microbiology ReviewsOpen Access

Yersinia pestis--etiologic agent of plague

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Authors

RPRobert D. PerryUniversity of Kentucky JFJacqueline D. FetherstonUniversity of Kentucky

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Implication

Review highlights the transmission biology and complex virulence mechanisms of Yersinia pestis across mammalian and flea hosts, suggesting eradication remains unlikely due to vast animal reservoirs.

Key Points

To provide an updated synthesis of the history, etiology, transmission epidemiology, clinical presentation, and public health dimensions of plague caused by Yersinia pestis.
Narrative review synthesizing historical literature, molecular research, and epidemiological data regarding Yersinia pestis biology and pathology.
Analysis of flea–rodent vector cycles, bacterial adaptation mechanisms across diverse host environments, and regulatory networks governing virulence factor expression.
Yersinia pestis maintains complex regulatory pathways and specialized virulence determinants that facilitate evasion of mammalian immune defenses and survival within flea vectors.
Disease eradication remains unfeasible because widespread mammalian wildlife hosts and associated flea populations maintain stable natural zoonotic reservoirs.

Cite This Study

Perry et al. (1997) studied this question.

synapsesocial.com/papers/6a121dea8edbaba0bf66ae33 https://doi.org/10.1128/cmr.10.1.35

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Implication

Review highlights the transmission biology and complex virulence mechanisms of Yersinia pestis across mammalian and flea hosts, suggesting eradication remains unlikely due to vast animal reservoirs.

Yersinia pestis--etiologic agent of plague

Discussion

Member takes

Implication

Key Points

Cite This Study

Yersinia pestis--etiologic agent of plague

Discussion

Member takes

Implication

Key Points

Cite This Study

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