Non-Invasive Parameters in Treated Hypertensive Patients Have Better Correlation With Target Organ Damage Than the Possibility of Predicting 5-Year Treatment Outcome

The objective of the research was to investigate which of routine non-invasive parameters could predict the occurrence of target organ damage and treatment outcome during 5-year follow-up in patients with arterial hypertension. The research included 176 patients (average age 66.9 9.3) with arterial hypertension who were previously treated for 144 90 months. Patient monitoring was continued for 63.6 months on average. Average values of 24-hour ABPM were 121.5 14.6 mmHg for systolic (SBP) and 69.1 9.2 mmHg for diastolic (DBP) pressure. The total of 36 (20.4%) patients had diabetes, while 115 (65.4%) patients had lipid disorder. Furthermore, 116 (63.4%) patients had left ventricular hypertrophy (LVH). Left ventricular mass index was, on average, 135.4 30.7 g/m 2 . During the follow-up period, we registered 21 (11.9%) new events, 3 (1.7%) of which were stokes, 6 (3.4%) were acute coronary events with accompanying revascularization, two stable angina pectoris (2.6%), two pacemaker insertions (2.6%), one acute thrombosis of leg artery (0.6%), one dementia (0.6%) and 6 (3.4%) new atrial fibrillations. Independent predictor for total new events was the size of left atrium (coefficient beta 0.295; p < 0.01). Patients with LVH had higher SBP and DBP values obtained from 24-hour ABPM and home measurement (p < 0.01). Independent predictor for the presence of LVH was the length of hypertension treatment (coefficient beta 0.180; p < 0.03). Predictors of lower values of creatinine clearance (for model p < 0.01) were age (beta 0.187; p < 0.02) and glycemic value (coefficient beta 0.232; p < 0.01). Routine noninvasive parameters in patients with arterial hypertension cannot predict 5-year treatment outcome during the treatment, but have a good correlation with damage of target organs.