Key result
Pediatric concussion links to altered functional brain connectivity at one month primarily in females.
Why the study?
Resting-state functional magnetic resonance imaging disturbances are common in pediatric concussion, but no studies had explicitly examined sex differences regarding this outcome.
Are there sex-specific differences in resting-state functional brain activity in pediatric concussion at one-month post-injury?
Population
29 children with concussion and greater than 12:1 matched controls
Comparison
Sex-based differences between children with concussion and matched healthy controls
Design
Secondary data analysis of matched case-control data
Authors
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May warrant sex-specific monitoring in female pediatric concussion recovery; hypothesis-generating for longitudinal outcome studies.
Cross-Sectional (n=390)
Yes
Are there sex-specific differences in resting-state functional brain activity in pediatric concussion at one-month post-injury?
p-value: p=<0.001
Females exhibit significant alterations in resting-state functional brain activity at one-month post-concussion that are minimally present in males, suggesting sex-specific recovery timelines.
Sharma et al. (2023) conducted a cross-sectional in Pediatric concussion (n=390). Concussion vs. Healthy controls was evaluated on Resting-state functional brain connectivity (rs-fMRI) differences (p=<0.001). At one-month post-injury, females with pediatric concussion demonstrated significant alterations in resting-state functional brain connectivity compared to healthy females, which were minimally present in males.
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