Key result
Male patients with acute mild traumatic brain injury showed increased intrinsic functional connectivity in motor, ventral stream, executive function, and cerebellum networks, and decreased connectivity in the visual network compared to female patients.
Why the study?
Mild TBI induces abnormal intrinsic functional connectivity within resting-state networks, but the role of sex in these connectivity changes after acute mild TBI remains to be estimated.
Does sex influence intrinsic functional connectivity in resting-state networks after acute mild traumatic brain injury?
Cross-Sectional (n=88)
No
Does sex influence intrinsic functional connectivity in resting-state networks after acute mild traumatic brain injury?
Male patients exhibit distinct patterns of abnormal intrinsic functional connectivity after acute mild TBI compared to females, suggesting sex-specific mechanisms of brain recombination and vulnerability.
Answers are grounded in this paper and cite their sources.
Sex differences in post-mTBI connectivity should not alter management; leaves open prognostic relevance pending longitudinal data.
Mild traumatic brain injury (TBI) is considered to induce abnormal intrinsic functional connectivity within resting-state networks. The objective of this study was to estimate the role of sex in intrinsic functional connectivity after acute mild TBI. We recruited a cohort of 54 patients (27 males and 27 females with mild TBI within 7 days post-injury) from the emergency department and 34 age-, education-matched healthy controls (17 males and 17 females). On the clinical scales, there were no statistically significant differences between males and females in either control group or mild TBI group. To detect whether there was abnormal sex difference on functional connectivity in resting state networks (RSNs), we performed independent component analysis (ICA) and a dual regression approach to investigate the between-subject voxel-wise comparisons of functional connectivity within seven selected RSNs. Compared to female patients, male patients showed increased intrinsic functional connectivity in motor network, ventral stream network, executive function network, cerebellum network, and decreased connectivity in visual network. Further analysis demonstrated a positive correlation between the functional connectivity in executive function network and insomnia severity index scores in male patients (r = 0.515, P = 0.006). The abnormality of the functional connectivity of RSNs in acute mild TBI showed the possibility of brain recombination after trauma, mainly concerning male-specific.
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Wang et al. (2018) conducted a cross-sectional in Acute mild traumatic brain injury (n=88). Male sex vs. Female sex was evaluated on Voxel-wise group differences in intrinsic network functional connectivity (p=<0.05). Male patients with acute mild traumatic brain injury showed increased intrinsic functional connectivity in motor, ventral stream, executive function, and cerebellum networks, and decreased connectivity in the visual network compared to female patients.
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