Why the study?
Do acute changes in plasma free fatty acids alter intramyocellular fat content and insulin resistance in healthy subjects?
Population
Healthy volunteers
Comparison
Lowering of plasma free fatty acids or… vs Baseline (before intervention)
Design
Other
Follow-up
4 hours
Authors
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Acute FFA increases may promote IMCL-TG accumulation and insulin resistance; hypothesis-generating for T2D mechanisms.
Do acute changes in plasma free fatty acids alter intramyocellular fat content and insulin resistance in healthy subjects?
Acute increases in plasma free fatty acids lead to corresponding increases in intramyocellular triglycerides and the development of insulin resistance, suggesting IMCL-TG accumulation is a key step in FFA-induced insulin resistance.
Boden et al. (2001) studied this question.
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