Key result
Short-term suppression of plasma free fatty acids with nicotinic acid did not improve insulin sensitivity or glucose tolerance compared to control when intramyocellular lipid was elevated (P>0.05).
Why the study?
Does short-term suppression of plasma free fatty acids with nicotinic acid improve insulin sensitivity in healthy men with elevated intramyocellular lipid?
Population
6 healthy men
Comparison
Nicotinic acid ingestion 30 min prior to and… vs Low carbohydrate/high fat diet alone
Design
Other
Authors
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No short-term benefit from nicotinic acid in elevated intramyocellular lipid; leaves open whether sustained lipid modulation affects insulin sensitivity.
Does short-term suppression of plasma free fatty acids with nicotinic acid improve insulin sensitivity in healthy men with elevated intramyocellular lipid?
p-value: p=>0.05
Short-term suppression of plasma free fatty acids does not immediately improve insulin sensitivity when intramyocellular lipid levels are elevated.
Johnson et al. (2006) studied Healthy (n=6). Nicotinic acid vs. Identical low carbohydrate/high fat diet without nicotinic acid was evaluated on Insulin sensitivity and glucose tolerance (p=>0.05). Short-term suppression of plasma free fatty acids with nicotinic acid did not improve insulin sensitivity or glucose tolerance compared to control when intramyocellular lipid was elevated (P>0.05).
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