Key result
Higher serum thiocyanate levels, an indicator of smoking status, were significantly associated with an increased risk of cerebral infarction (OR 3.00; 95% CI 1.06-8.48; p<0.05).
Why the study?
Does serum thiocyanate level, as an indicator of smoking status, predict the risk of new stroke onset in a community-based cohort?
Case-Control
No
Does serum thiocyanate level, as an indicator of smoking status, predict the risk of new stroke onset in a community-based cohort?
Serum thiocyanate is a useful objective biomarker of smoking status that significantly predicts the risk of cerebral infarction, overcoming the limitations and misclassification of self-reported smoking history.
Thiocyanate may aid objective smoking assessment for infarction risk; leaves open prospective validation before clinical use.
The case subjects were 67 stroke patients (27 males and 40 females, mean age 65.7+/-7.1), who suffered from stroke attack and had participated in annual medical check-up between 1987 and 1988 at Oyabe Public Health Center. The controls, which were adjusted for sex, age and blood pressure level with the case subjects, were selected from participants attending their annual medical check-up in 1987-1988. The serum thiocyanate level of case subjects were significantly higher than that of controls (p<0.05). The usefulness of measurement of serum thiocyanate level as an indicator of smoking status was assessed by using multiple logistic regression analysis adjusting for body mass index, mean blood pressure, and serum cholesterol was found. An odds ratio of 3.00 (95% confidence interval: 1.06-8.48, p<0.05) in cerebral infarction. It is considered that serum thiocyanate may be useful as an indicator of smoking status to assess the relationship with stroke onset, especially for cerebral infarction.
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Wang et al. (2001) conducted a case-control in Stroke. Serum thiocyanate level vs. Controls (adjusted for sex, age, and blood pressure) was evaluated on Cerebral infarction (OR 3.00, 95% CI 1.06-8.48, p=<0.05). Higher serum thiocyanate levels, an indicator of smoking status, were significantly associated with an increased risk of cerebral infarction (OR 3.00; 95% CI 1.06-8.48; p<0.05).
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