What question did this study set out to answer?

To determine how hormonal contraceptive use and menstrual cycle phases influence the composition and diversity of female microbiomes across four distinct body sites.

April 21, 2022Human ReproductionOpen Access

The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle

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Authors

MKMaria Christine KrogUniversity of Copenhagen LHLuisa W. HugerthUppsala University EFEmma FranssonUppsala University

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Implication

Cohort study reveals menstrual cycle phase alters vaginal and oral microbiomes in healthy young women, indicating cycle timing is vital for clinical evaluation.

Key Points

To determine how hormonal contraceptive use and menstrual cycle phases influence the composition and diversity of female microbiomes across four distinct body sites.
Analyzed a cohort of 160 healthy Danish women using non-hormonal contraception (n = 54), combined oral contraceptives (n = 52), or levonorgestrel intrauterine systems (n = 54).
Collected oral, vaginal, rectal, and faecal samples across menses, follicular, and luteal phases, profiling communities with shotgun sequencing and measuring plasma oestradiol and progesterone.
Hormonal contraceptive use showed no significant association with microbiome composition or microbial diversity across any of the evaluated body sites.
Vaginal dysbiosis (<60% Lactobacillus spp.) occurred in 58% (89/154) of women during menses, declining to 32% (49 women, P < 0.001) in the follicular phase and 29% (44 women, P < 0.001) in the luteal phase.
Post-menses expansion of Lactobacillus spp. correlated positively with serum oestradiol levels (r = 0.11, P < 0.001), while salivary bacterial diversity reached its lowest point during menstruation and gut bacteria remained stable.

Cite This Study

Krog et al. (2022) studied this question.

synapsesocial.com/papers/6a123776375951284434424b https://doi.org/10.1093/humrep/deac094

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Implication

Cohort study reveals menstrual cycle phase alters vaginal and oral microbiomes in healthy young women, indicating cycle timing is vital for clinical evaluation.

The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle

Discussion

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Implication

Key Points

Cite This Study

The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle

Discussion

Member takes

Implication

Key Points

Cite This Study

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