Key result
Serum antibodies against natural streptokinase were three times higher than those against a recombinant mutated streptokinase in samples from normal individuals and acute myocardial infarction patients.
Why the study?
Does a recombinant mutant streptokinase reduce reactivity with antistreptokinase antibodies compared to natural streptokinase in human sera?
Cross-Sectional (n=123)
Does a recombinant mutant streptokinase reduce reactivity with antistreptokinase antibodies compared to natural streptokinase in human sera?
A recombinant mutant streptokinase lacking 42 C-terminal amino acids shows significantly reduced antibody reactivity compared to natural streptokinase, suggesting potential as a less immunogenic alternative.
Answers are grounded in this paper and cite their sources.
May support less immunogenic streptokinase development; hypothesis-generating and should not yet change practice.
Streptokinase is widely used as an anticoagulant drug for the treatment of heart attacks. Because of antibody production against injected drug in individuals consuming streptokinase and causing allergic reactions, streptokinase treatment effects become neutral. Recombinant mutant type of streptokinase was prepared by removing of 42 amino acids from the C terminal region. ELISA plates were coated by natural and mutant streptokinase as antigen. Ninety-six normal serum samples as well as 27 streptokinase consumer serum samples (patients with acute myocardial infraction) were analyzed. The results showed that serum antibodies against natural streptokinase were three times more than those against the mutated streptokinase. In case of preserving thrombolytic activity, mutated streptokinase can be used as an alternative of the natural form.
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Bandehpour et al. (2012) conducted a cross-sectional in Acute myocardial infarction (n=123). Mutated streptokinase vs. Natural streptokinase was evaluated on Reactivity with total antistreptokinase antibodies. Serum antibodies against natural streptokinase were three times higher than those against a recombinant mutated streptokinase in samples from normal individuals and acute myocardial infarction patients.
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