September 1, 1994HeartOpen Access

Pre-dosing antibody levels and efficacy of thrombolytic drugs containing streptokinase.

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Why the study?

Does pretreatment streptokinase resistance titre influence coronary patency in previously unexposed patients with acute myocardial infarction receiving streptokinase or anistreplase?

Population

124 previously unexposed patients presenting within six hours of onset of acute myocardial infarction.

Design

Cohort

Follow-up

24 hours

Authors

JGJ D GemmillUniversity Hospital Ayr KHKaren HoggSeafish FDF G DunnGeneral Cardiology

Discussion

Member takes

Implication

May warrant caution with streptokinase in high-titre patients; leaves open prospective validation of titre-guided thrombolysis in AMI.

Structured PICO

Does pretreatment streptokinase resistance titre influence coronary patency in previously unexposed patients with acute myocardial infarction receiving streptokinase or anistreplase?

Population

124 previously unexposed patients presenting within six hours of onset of acute myocardial infarction.

Intervention

Streptokinase 1.5 MIU as intravenous infusion over 60 minutes or anistreplase 30 units as intravenous injection over five minutes.

Outcome

Coronary patency assessed angiographically at 90 minutes and 24 hours.surrogate

Pretreatment streptokinase resistance titres negatively influence the angiographic efficacy of streptokinase-containing thrombolytic drugs in acute myocardial infarction.

Cite This Study

Gemmill et al. (1994) studied this question.

synapsesocial.com/papers/6a20a1384e12e6ef5d91161e https://doi.org/10.1136/hrt.72.3.222

View Full Paper

Ask AI

Bookmark

Pre-dosing antibody levels and efficacy of thrombolytic drugs containing streptokinase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pre-dosing antibody levels and efficacy of thrombolytic drugs containing streptokinase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider