Key result
Exposure to streptokinase or anistreplase resulted in significantly elevated antistreptokinase antibody and neutralization titres from 4 days up to 54 months compared to unexposed controls (P<0.01).
Why the study?
Does administration of streptokinase or anistreplase increase antistreptokinase antibody and neutralization titres up to 54 months post-exposure?
Observational (n=275)
Does administration of streptokinase or anistreplase increase antistreptokinase antibody and neutralization titres up to 54 months post-exposure?
p-value: p=<0.01
Antistreptokinase antibodies remain elevated from 4 days to at least 54 months after administration, suggesting re-administration should be avoided during this extended period.
No takes yet. Share an insight, caveat, or question.
Supports caution with re-exposure up to 54 months; leaves open need for prospective outcome trials.
LEE et al. (1993) conducted an observational in Myocardial infarction (n=275). Streptokinase or anistreplase vs. No previous exposure to thrombolysis was evaluated on Antistreptokinase antibody and neutralization titres (p=<0.01). Exposure to streptokinase or anistreplase resulted in significantly elevated antistreptokinase antibody and neutralization titres from 4 days up to 54 months compared to unexposed controls (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: