Key result
Delayed contrast-enhanced MRI detected myocardial hyperenhancement in 90.9% of patients with cardiac sarcoidosis versus 0% without, predominantly localized in basal and subepicardial layers.
Why the study?
Does delayed contrast-enhanced MRI identify specific topographic localization of myocardial lesions and correlate with LV dysfunction and BNP levels in patients with cardiac sarcoidosis?
Population
40 patients with sarcoidosis (11 with cardiac sarcoidosis, 29 with extracardiac sarcoidosis)
Comparison
Delayed contrast-enhanced MRI using a 29-segment… vs Patients with extracardiac sarcoidosis
Design
Cross-sectional
Authors
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May aid lesion localization in suspected cardiac sarcoidosis; leaves open prospective validation for outcomes or therapy guidance.
Observational (n=40)
Does delayed contrast-enhanced MRI identify specific topographic localization of myocardial lesions and correlate with LV dysfunction and BNP levels in patients with cardiac sarcoidosis?
Absolute Event Rate: 90.9% vs 0%
Delayed contrast-enhanced MRI reveals that myocardial lesions in cardiac sarcoidosis predominantly localize to the basal and subepicardial myocardium, and their extent correlates with LV dysfunction and BNP levels.
Ichinose et al. (2008) conducted an observational in Cardiac sarcoidosis (n=40). Delayed contrast-enhanced MRI vs. Patients with extracardiac sarcoidosis was evaluated on Presence of myocardial hyperenhancement. Delayed contrast-enhanced MRI detected myocardial hyperenhancement in 90.9% of patients with cardiac sarcoidosis versus 0% without, predominantly localized in basal and subepicardial layers.
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