Key result
Prior DOAC treatment was associated with smaller infarct volume and a decreased risk of more proximal artery occlusion (OR 0.34, P=0.015) compared with no anticoagulation.
Why the study?
Does prior DOAC therapy reduce infarct volume and proximal artery occlusion in patients with acute ischemic stroke and non-valvular atrial fibrillation?
Cohort (n=330)
Does prior DOAC therapy reduce infarct volume and proximal artery occlusion in patients with acute ischemic stroke and non-valvular atrial fibrillation?
Effect estimate: OR 0.34
p-value: p=0.015
Prior DOAC therapy in patients with non-valvular atrial fibrillation is associated with smaller infarct volumes and less proximal artery occlusion upon acute ischemic stroke presentation compared to no anticoagulation.
No takes yet. Share an insight, caveat, or question.
Prior DOAC use was associated with milder AF-related strokes; hypothesis-generating, should not yet change practice.
Sakamoto et al. (2018) conducted a cohort in Acute ischemic stroke and non-valvular atrial fibrillation (n=330). Direct oral anticoagulant (DOAC) vs. No anticoagulant was evaluated on More proximal artery occlusion (OR 0.34, p=0.015). Prior DOAC treatment was associated with smaller infarct volume and a decreased risk of more proximal artery occlusion (OR 0.34, P=0.015) compared with no anticoagulation.
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