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A chip platform for thermally controlled biochemistry is presented comprising postprocessed thermally isolated heated reaction sites atop a application-specific integrated circuit (ASIC) using proportional-integral-differential (PID) feedback temperature control. The 384 sites can be individually programmed over <tex-math notation="LaTeX">25~∘</tex-math> C– <tex-math notation="LaTeX">125~∘</tex-math> C, with thermal crosstalk below the <tex-math notation="LaTeX">± 0.12~∘</tex-math> C precision. Double-strand deoxyribonucleic-acid (DNA) purification via selective melting is demonstrated, with 70% retention of perfectly matched sequences, while 55% of those with two mismatched base-pairs are removed.
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Coln et al. (2025) studied this question.
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