Key result
Isoleucine-tryptophan, whey protein hydrolysate, and captopril effectively blunted systolic blood pressure rise in hypertensive rats (-42 ± 3, -38 ± 5, and -55 ± 4 mm Hg vs. placebo, respectively).
Why the study?
Does isoleucine-tryptophan or whey protein hydrolysate reduce systolic blood pressure in spontaneously hypertensive rats?
Population
spontaneously hypertensive rats (n = 60)
Comparison
Isoleucine-tryptophan, a whey protein… vs No supplement (Placebo) or intact whey protein
Design
Preclinical
Follow-up
14 weeks
Authors
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Supports whey peptide exploration as antihypertensive additives; leaves open human translation and clinical utility.
Does isoleucine-tryptophan or whey protein hydrolysate reduce systolic blood pressure in spontaneously hypertensive rats?
Whey protein hydrolysate and isoleucine-tryptophan inhibit plasma ACE and attenuate hypertension in spontaneously hypertensive rats, suggesting potential as food additives.
Martin et al. (2015) studied Hypertension (spontaneously hypertensive rats) (n=60). Isoleucine-tryptophan, whey protein hydrolysate, or captopril vs. Placebo or intact whey protein was evaluated on Systolic blood pressure. Isoleucine-tryptophan, whey protein hydrolysate, and captopril effectively blunted systolic blood pressure rise in hypertensive rats (-42 ± 3, -38 ± 5, and -55 ± 4 mm Hg vs. placebo, respectively).
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