Key result
Pre-impaired fasting glucose linked to lower FMD versus levels under 90 mg/dL.
Why the study?
Little information is available on the relationships of fasting blood glucose levels, including high normal blood glucose and impaired fasting glucose, with endothelial function.
Is a pre-impaired fasting glucose state associated with endothelial dysfunction in a general hospital population?
Cross-Sectional (n=7,265)
Yes
Is a pre-impaired fasting glucose state associated with endothelial dysfunction in a general hospital population?
Absolute Event Rate: 5.9% vs 6.7%
p-value: p=<0.001
Even a pre-impaired fasting glucose state (95-99 mg/dL) is associated with endothelial dysfunction, suggesting cardiovascular risk begins at lower glucose thresholds than previously recognized.
No takes yet. Share an insight, caveat, or question.
May signal early endothelial risk below prediabetes thresholds; leaves open causal confirmation and intervention trials.
Yamaji et al. (2020) conducted a cross-sectional in Endothelial dysfunction (n=7,265). Fasting blood glucose levels vs. FBG <100 mg/dL or <90 mg/dL was evaluated on Flow-mediated vasodilation (FMD) (p=<0.001). A pre-impaired fasting glucose state (95-99 mg/dL) and higher FBG levels were significantly associated with lower flow-mediated vasodilation compared to FBG <90 mg/dL (p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: