Key result
In asymptomatic childhood cancer survivors, increased myocardial extracellular volume fraction significantly correlated with lower peak VO2 (r = -0.52), higher cumulative anthracycline dose (r = 0.40), and ventricular wall thinning.
Why the study?
Do CMR-derived myocardial T1 and ECV correlate with exercise capacity, cumulative anthracycline dose, and ventricular remodeling in childhood cancer survivors?
Population
30 childhood cancer survivors, at least 2 years following anthracycline treatment, with normal LVEF.
Design
Cross-sectional
Authors
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Supports ECV as fibrosis marker tied to exercise impairment in survivors; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=30)
No
Do CMR-derived myocardial T1 and ECV correlate with exercise capacity, cumulative anthracycline dose, and ventricular remodeling in childhood cancer survivors?
Effect estimate: r = -0.52
p-value: p=0.005
Myocardial T1 mapping and ECV identify early subclinical diffuse fibrosis and ventricular remodeling in childhood cancer survivors with normal ejection fraction post-anthracycline therapy.
Tham et al. (2013) conducted a cross-sectional in Subclinical anthracycline cardiotoxicity in childhood cancer survivors (n=30). Anthracycline therapy was evaluated on Correlation between myocardial extracellular volume fraction (ECV) and peak VO2 (r = -0.52, p=0.005). In asymptomatic childhood cancer survivors, increased myocardial extracellular volume fraction significantly correlated with lower peak VO2 (r = -0.52), higher cumulative anthracycline dose (r = 0.40), and ventricular wall thinning.
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