Key result
Eosinophils maintain perivascular adipose tissue and vascular contractility via adrenergic, nitric oxide, and adiponectin signaling.
Why the study?
Understanding communication among cell populations in perivascular adipose tissue is important for exploring therapeutic options in obesity-related cardiovascular complications.
Eosinophils in perivascular adipose tissue regulate vascular contractility via adrenergic, nitric oxide, and adiponectin pathways, suggesting a potential target for obesity-related cardiovascular disease.
New Findings What is the topic of this review? The review discusses how eosinophils can contribute to the function of perivascular adipose tissue and explores the mechanisms involved. What advances does it highlight? Understanding the communication between the cell populations that constitute perivascular adipose tissue function is important for exploring therapeutic options in the treatment of obesity‐related cardiovascular complications. This article highlights that eosinophils are able to contribute directly to healthy perivascular adipose tissue function. These immune cells contribute to adrenergic signalling and nitric oxide‐ and adiponectin‐dependent mechanisms in perivascular adipose tissue. Abstract Perivascular adipose tissue is a heterogeneous tissue that surrounds most blood vessels in the body. This review focuses on the contribution of eosinophils located within the adipose tissue to vascular contractility. A high‐fat diet reduces the number of these immune cells within perivascular adipose tissue, and this loss is linked to an increase in vascular contractility and hypertension. We explored the mechanisms by which eosinophils contribute to this function using genetically modified mice, ex vivo assessment of contractility and pharmacological tools. We found that eosinophils contribute to adrenergic signalling and nitric oxide‐ and adiponectin‐dependent mechanisms in perivascular adipose tissue. It is now important to explore whether manipulation of these pathways in obesity can alleviate cardiovascular complications, in order to determine whether eosinophils are a valid target for obesity‐related disease.
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Saxton et al. (2020) conducted a review in Obesity-related cardiovascular complications. Eosinophils in perivascular adipose tissue was evaluated on Vascular contractility. Eosinophils contribute to healthy perivascular adipose tissue function and vascular contractility via adrenergic signaling and nitric oxide- and adiponectin-dependent mechanisms.
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