Key result
Both the endothelium and perivascular adipose tissue modulate vascular contractility through common pathways, and their dysfunction is implicated in obesity and cardiovascular diseases.
Design
Review
Authors
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Supports mechanistic research on PVAT-endothelium crosstalk in cardio-metabolic disease; leaves open whether targeting these pathways improves clinical outcomes.
This review highlights the shared mechanisms between perivascular adipose tissue and the endothelium in modulating vascular tone and their dysfunction in cardio-metabolic disorders.
Zaborska et al. (2016) conducted a review in Vascular tone modulation and dysfunction. Perivascular adipose tissue (PVAT) and endothelium was evaluated. Both the endothelium and perivascular adipose tissue modulate vascular contractility through common pathways, and their dysfunction is implicated in obesity and cardiovascular diseases.
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