Key result
Perivascular adipose tissue has a dual regulatory role in modulating vessel function by releasing both relaxation and constricting factors, which are impaired in obesity and hypertension.
Perivascular adipose tissue plays a dual regulatory role in vascular tone homeostasis, and its dysfunction in obesity or lipoatrophy may contribute to vascular disorders, representing a potential therapeutic target.
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May position PVAT modulation as therapeutic strategy in obesity-related hypertension; leaves open trials to confirm causality and efficacy.
Yu-Jing Gao (2007) conducted a review in Vascular dysfunction and hypertension. Perivascular adipose tissue has a dual regulatory role in modulating vessel function by releasing both relaxation and constricting factors, which are impaired in obesity and hypertension.
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