Why the study?
The exact mechanism of vascular dysfunction in obesity is still not well clarified.
Design
Review
Key result
Physical activity and diet mitigate obesity-induced perivascular adipose tissue dysfunction by reducing oxidative stress and restoring the balance of PVAT-derived factors.
Authors
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May inform obesity-related vascular strategies; leaves open need for trials confirming clinical outcomes.
This review highlights the mechanisms of obesity-induced perivascular adipose tissue dysfunction and the therapeutic potential of lifestyle interventions like diet and exercise.
Stanek et al. (2021) conducted a review in Obesity-induced perivascular adipose tissue (PVAT) dysfunction. Physical activity and diet was evaluated. Physical activity and diet mitigate obesity-induced perivascular adipose tissue dysfunction by reducing oxidative stress and restoring the balance of PVAT-derived factors.