Key result
Perivascular adipose tissue dysfunction in obesity, diabetes, or hypertension shifts its paracrine influence to a proinflammatory state, contributing to cardiovascular disease.
Perivascular adipose tissue plays a critical paracrine role in vascular health, and its dysfunction in metabolic diseases represents a potential novel pharmacological target for cardiovascular disease.
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May identify a novel target in metabolic CVD; extends mechanistic insights but leaves open clinical translation.
Fernández-Alfonso et al. (2017) conducted a review in Cardiovascular disease. Perivascular adipose tissue dysfunction in obesity, diabetes, or hypertension shifts its paracrine influence to a proinflammatory state, contributing to cardiovascular disease.
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