Key result
Perivascular adipose tissue actively regulates blood vessel tone and contributes to atherosclerosis through paracrine secretion of bioactive factors such as adipokines and cytokines.
Why the study?
Although perivascular adipose tissue surrounds most blood vessels, its physiological and pathological significance has long been ignored.
This review highlights the active role of perivascular adipose tissue in regulating vascular function and its contribution to hypertension and atherosclerosis.
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PVAT modulation merits investigation as a vascular therapy target; leaves open translation to clinical interventions in atherosclerosis.
Hu et al. (2020) conducted a review in Hypertension and atherosclerosis. Perivascular adipose tissue (PVAT) was evaluated. Perivascular adipose tissue actively regulates blood vessel tone and contributes to atherosclerosis through paracrine secretion of bioactive factors such as adipokines and cytokines.
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