Key result
Platelet MMP-2 expression correlates with carotid stenosis severity in patients with CAD and chronic HIV.
Why the study?
Platelets participate in atherogenesis through mechanisms not fully clarified, and the role of platelet-derived MMP-2 in atherosclerotic lesion formation was unknown.
Does platelet-derived MMP-2 trigger the initial phases of atherosclerosis?
Population
Double knockout mice lacking LDLR and hematopoietic MMP-2, LDLR-/- mice, and patients with CAD and chronic HIV infection
Comparison
MMP-2 deficiency or inhibition vs controls across mouse models, transfusions, and translational human cohorts
Design
Preclinical animal, in vitro, and translational human study
Follow-up
4 months
Authors
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Should not yet change practice in CAD or HIV; leaves open platelet MMP-2 as atherosclerosis trigger.
Does platelet-derived MMP-2 trigger the initial phases of atherosclerosis?
Platelet-derived MMP-2 plays a pivotal role in triggering the initial phases of atherosclerosis by activating endothelial PAR-1, suggesting a potential new therapeutic target for prevention.
Momi et al. (2021) studied Atherosclerosis. Platelet MMP-2 knockout or expression vs. Wild-type or normal MMP-2 expression was evaluated on Atherosclerotic lesion formation and degree of carotid artery stenosis. Platelet surface expression of MMP-2 highly significantly correlated with the degree of carotid artery stenosis in patients with CAD and chronic HIV infection.
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