Key result
Matrix metalloproteinase-2 of human carotid atherosclerotic plaques promotes platelet activation.
Why the study?
Does MMP-2 expression in human carotid atherosclerotic plaques promote platelet activation and correlate with subsequent ischemic events?
Population
Carotid plaques from 81 patients undergoing endarterectomy, and gel-filtered platelets from healthy volunteers
Comparison
Assessment of MMP-2 expressed in atherosclerotic… vs Plaques not potentiating platelet aggregation…
Design
Cohort
Authors
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Associated with higher ischemic event rates; hypothesis-generating for MMP-2 inhibition trials.
Does MMP-2 expression in human carotid atherosclerotic plaques promote platelet activation and correlate with subsequent ischemic events?
MMP-2 in human carotid atherosclerotic plaques promotes platelet activation, and its elevated activity is associated with a higher rate of subsequent ischemic cerebrovascular events.
Lenti et al. (2014) studied Carotid atherosclerotic plaques. Matrix metalloproteinase-2 was evaluated on Platelet activation. Matrix metalloproteinase-2 of human carotid atherosclerotic plaques promotes platelet activation.
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