Key result
The spatial distribution of MMPs and TIMPs in carotid atherosclerotic lesions was highly heterogeneous, reflecting lesion location, size, and composition.
Authors
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Lesion heterogeneity may limit uniform MMP/TIMP targeting; leaves open spatially resolved therapeutic validation.
Observational
Choudhary et al. (2006) conducted an observational in Carotid atherosclerosis. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) was evaluated on Spatial distribution of TIMP mass and MMP mass and activity. The spatial distribution of MMPs and TIMPs in carotid atherosclerotic lesions was highly heterogeneous, reflecting lesion location, size, and composition.
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