Key result
High serum TIMP-1 linked to ~189% greater odds of carotid plaques versus low levels.
Why the study?
Experimental studies suggested that MMPs and TIMPs are involved in vascular remodeling, but their relationships with carotid atherosclerosis and aortic stiffness in populations were unclear.
Are high serum TIMP-1 levels associated with increased carotid atherosclerosis and aortic stiffness in men free of coronary heart disease?
Population
238 men free of coronary heart diseases, mean age 56.5 years, 57.1% hypertensive
Comparison
High serum TIMP-1 levels (tertile 3) vs low serum TIMP-1 levels (tertile 1)
Design
Population-based observational study with carotid ultrasound and PWV assessment
Authors
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Supports TIMP-1 as plaque marker in CHD-free men; leaves open causality and progression links.
Observational (n=238)
Are high serum TIMP-1 levels associated with increased carotid atherosclerosis and aortic stiffness in men free of coronary heart disease?
Odds Ratio: 2.89 (95% CI 1.12–7.47)
p-value: p=< 0.01
High serum TIMP-1 levels are independently associated with the presence of carotid plaques, suggesting a role in plaque formation, but not with aortic stiffness or intima-media thickness after adjusting for age and blood pressure.
Zureik et al. (2005) conducted an observational in Free of coronary heart diseases (n=238). High serum TIMP-1 levels (tertile 3) vs. Low serum TIMP-1 levels (tertile 1) was evaluated on Presence of carotid plaques (OR 2.89, 95% CI 1.12-7.47, p=< 0.01). High serum TIMP-1 levels were associated with a significantly increased odds of carotid plaques compared to low levels (OR 2.89; 95% CI 1.12-7.47; P<0.01).
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