Key result
Plasma osteoprotegerin (OPG) concentration was significantly higher in patients with carotid atherosclerosis (P<0.001), demonstrating high diagnostic accuracy (AUC 0.943).
Why the study?
It was unknown whether local extracellular matrix remodeling changes in atheromatous artery walls have systemic reflection and clinical utility in patients with carotid atherosclerosis.
Do extracellular matrix remodeling factors (MMP-2, MMP-9, OPG, FN) differ between patients with carotid atherosclerosis and healthy volunteers?
Population
20 patients undergoing routine carotid endarterectomy and 40 healthy volunteers
Comparison
Patients undergoing carotid endarterectomy vs healthy volunteers
Design
Case-control study
Authors
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Plasma ECM markers may not reflect local plaque remodeling; leaves open their value as systemic biomarkers in atherosclerosis.
Case-Control (n=60)
Do extracellular matrix remodeling factors (MMP-2, MMP-9, OPG, FN) differ between patients with carotid atherosclerosis and healthy volunteers?
Effect estimate: AUC 0.943
p-value: p=<0.001
Osteoprotegerin (OPG) demonstrates high potential as a systemic biomarker for advanced carotid atherosclerosis.
Sapa-Wojciechowska et al. (2020) conducted a case-control in Carotid atherosclerosis (n=60). Carotid atherosclerosis vs. Healthy volunteers was evaluated on Plasma osteoprotegerin (OPG) concentration (AUC 0.943, p=<0.001). Plasma osteoprotegerin (OPG) concentration was significantly higher in patients with carotid atherosclerosis (P<0.001), demonstrating high diagnostic accuracy (AUC 0.943).
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