Key result
Carotid atherosclerotic plaques with a thin fibrous cap had a 7.8-fold higher MMP-1 transcript level compared to those with a thick cap (P=0.006).
Population
50 atherosclerotic plaques removed from patients undergoing carotid endarterectomy
Design
Cross-sectional
Authors
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MMP transcript levels vary with carotid plaque histology; hypothesis-generating for instability biomarkers, prospective validation required.
Observational (n=50)
Effect estimate: 7.8-fold higher
p-value: p=0.006
MMP-1 and MMP-12 transcript levels are significantly elevated in unstable carotid plaques, suggesting their role in determining atherosclerotic plaque stability.
Morgan et al. (2004) conducted an observational in Carotid atherosclerotic plaques (n=50). Thin fibrous cap vs. Thick fibrous cap was evaluated on MMP-1 transcript level (7.8-fold higher, p=0.006). Carotid atherosclerotic plaques with a thin fibrous cap had a 7.8-fold higher MMP-1 transcript level compared to those with a thick cap (P=0.006).
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