January 1, 2009Cerebrovascular Diseases
Reproducibility of Measures of Visit-to-Visit Variability in Blood Pressure after Transient Ischaemic Attack or Minor Stroke
Key result
Visit-to-visit variability in systolic blood pressure was reproducible over time within individuals (ICC 0.32, p<0.0001 in UK-TIA; ICC 0.18, p=0.0007 in ECST), demonstrating it is not random.
Why the study?
Is visit-to-visit blood pressure variability reproducible over time in patients with TIA or minor stroke?
Population
Patients with a transient ischaemic attack or minor ischaemic stroke from two large trials
Design
Cohort
Authors
Discussion
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Member takes
Implication
May inform prognosis after TIA/minor stroke; leaves open whether targeting variability improves outcomes.
Study Design
Type
Observational
Multicenter
Yes
Structured PICO
Is visit-to-visit blood pressure variability reproducible over time in patients with TIA or minor stroke?
P
Population
Patients with a transient ischaemic attack (TIA) or minor ischaemic stroke from two large trials (UK-TIA Aspirin Trial and European Carotid Surgery Trial)
I
Intervention
Measurement of visit-to-visit blood pressure variability
O
Outcome
Reproducibility of mean and several different measures of variability for both systolic (SBP) and diastolic BP (DBP)surrogate
Main Result
Effect estimate: ICC 0.32
p-value: p=<0.0001
Visit-to-visit blood pressure variability in patients with TIA or minor stroke is reproducible and not merely random, suggesting it could provide prognostic information.
Cite This Study
Howard et al. (2009) conducted an observational in Transient ischaemic attack (TIA) or minor ischaemic stroke. Visit-to-visit blood pressure variability was evaluated on Reproducibility (intraclass correlation) of standard deviation of systolic blood pressure (ICC 0.32, p=<0.0001). Visit-to-visit variability in systolic blood pressure was reproducible over time within individuals (ICC 0.32, p<0.0001 in UK-TIA; ICC 0.18, p=0.0007 in ECST), demonstrating it is not random.